Sleeve gastrectomy and pancreas omentoplasty improved β cell insulin expression and interleukin-1β serum level in non-obese diabetes mellitus rat

Background: Diabetes mellitus is one of the health problems that growing rapidly today. In Asia, majority population are non-obese with Type 2 Mellitus (T2DM). Two main defects T2DM, insulin resistance and impaired secretion due to reduced pancreatic β cells. Persistent metabolic stress hyperglycemic conditions, causes inflammation islets Langerhans. Interleukin-1β (IL-1β) signaling most frequent pathway inducing cell dysfunction. The bariatric Sleeve Gastrectomy (SG) procedure increases particular hormone which stimulates growth production. Aside from role as a blood glucose regulator, also plays in anti-inflammatory modulation. Omentoplasty can be used wrap organ or tissue structures. Omentum has unique biological functions, including promote regeneration effect. study evaluates effect pancreas procedures on expression serum levels diabetes subjects.Methods: Experimental "post-test control group design" 27 rats was divided into 3 groups: K (control), P1 (Sleeve Gastrectomy), P2 + Omentoplasty). 10 days after procedure, we evaluated cells using monoclonal antibody anti-insulin stain IL-1β rat Enzyme-Linked Immunosorbent Assay (ELISA) kit. Statistical analysis Kruskal Wallis Mann Whitney test. Correlation test Spearman.Results: increased (p=0.020), compared control. While significantly all groups (p<0.001) Moderate negative correlation (r = -0.476) between levels.Conclusion: gastrectomy omentoplasty decreased IL-1 mellitus.